| TREATMENT OF CHRONIC HEPATITIS C
Standard Therapy
Hoofnagle JH, Mullen KD, Jones DB, et al. Treatment of chronic non-A,
non-B hepatitis with recombinant human alpha interferon: A
preliminary report. New Engl J Med 1986; 315:1575-1578.
Davis GL, Balart LA, Schiff ER, et al. Treatment of chronic hepatitis
C with recombinant interferon alpha: A multicenter randomized,
controlled trial. New Engl J Med 1989; 321:1501-1506.
Marcellin P, Boyer N, Giostra, et al. Recombinant human alpha- interferon
in patients with chronic non A non B hepatitis: a multicenter
randomized controlled trial from France. Hepatology 1991;
13:393-397.
Causse x, Godinot H, Ouzan D, et al. Comparison of 1 or 3 MU of
interferon alfa-2b and placebo in patients with chronic non-A
non-B hepatitis. Gastroenterology 1991; 101:497-502.
TinŽ F, Margin S, Craxi A, Pagliaro L. Interferon for non-A, non-
B chronic Hepatitis: a meta-analysis of randomized clinical
trials. J Hepatol 1991; 13:192-199.
Alternative regimens: Higher dose, Longer duration
Beloqui O, Prieto J, Suarez M, Gil B, Qian CH, Garcia N, Civeira
MP. N-acetyl cysteine enhances the response to interferon-alpha
in chronic hepatitis C: a pilot study. J Interferon Res 1993;
13:279-282.
Kakumu S, Yoshioka K, Wakita T, Ishikawa T, Takayanagi M, Higashi
Y. A pilot study of ribavirin and interferon beta for the
treatment of chronic hepatitis C. Gastroenterology 1993; 105:507-
512.
Liaw YF, Sheen IS, Lin SM, Chen TJ, Chu CM. Effects of prednisolone
pretreatment in interferon alfa therapy for patients with chronic
non-A, non-B (C) hepatitis. Liver 1993; 13:46-50.
Alternatives to Interferon
Camps J, Garcia N, Riezu-Boj JI, Civiera MP, Prieto J. Ribavirin
in the treatment of chronic hepatitis C unresponsive to alfa
interferon. J Hepatol 1993; 19:408-412.
Bodenheimer HC, Lindsay K, Davis GL, et al. Ribavirin treatment
of chronic hepatitis C. Hepatology 1994; 20:(abstract in press).
SPECIAL PATIENT GROUPS
Decompensated Cirrhosis
Dimopoulou M, Fafoutis K, Basiliou K, Ketikoglou J, Karvountzis
G. Interferon alfa-2a for decompensated liver disease caused
by wither chronic hepatitis B or C: preliminary results of
a pilot study. Gut 1993; 34 (suppl 2):S104-105.
HIV infected patients
Eyster ME, Diamondstone LS, Lien JM, Ehmann WC, Quan S, Goedert
JJ. The natural history of hepatitis C virus infection in
multitransfused hemophiliacs: Effects of coinfection with
human immunodeficiency virus. Acquir Immune Defic Syndr 1993;
6:602.
Eyster ME, Fried MW, DiBisceglie AM, Goedert JJ. Increasing HCV
RNA levels in hemophiliacs: Relationship to HIV infection
and liver disease. Blood 1994; (in press).
Boyer N, Marcellin P. Degott C, Degos F, Saimot AG, Erlinger S,
Benhamou JP. Recombinant interferon-alpha for chronic hepatitis
C in patients positive for antibody to human immunodeficiency
virus. J Infect Dis 1992; 165:723-726.
Hemophiliacs
Makis M, Preston FR, Triger DR, Underwood JC, Westlake L, Adelman
MI. A randomized controlled trial of recombinant interferon-alpha
in chronic hepatitis C in hemophiliacs. Blood 1991; 78:1672-1677.
Transplant Recipients
Lim HL, Lau GK, Davis GL, Dolson DJ, Lau JYN. Cholestatic hepatitis
leading to hepatic failure in a patients with organ- transmitted
hepatitis C virus infection. Gastroenterology 1994; 106:248-251.
Ferrel LD, Wright TL, Roberts J, Ascher N, Lake J. Hepatitis C viral
infection in liver transplant recipients. Hepatology 1992; 16:865-876.
Wright HI, Gavaler JS, Van Thiel DH. Preliminary experience with
alpha-2b interferon therapy of viral hepatitis in liver allograft
recipients. Transplantation 1992; 53:121-124.
Asymptomatic Carriers
Naito M, Hayashi N, Hagiwara H, Hiram N, Kasahara A, Fusamato H,
Kamada T. Serum hepatitis C virus RNA quantity and histological
features of hepatitis C virus carriers with persistently normal
ALT levels. Hepatology 1994; 19:871-875.
Extrahepatic Disease
Lunel F, Musset L, Cacoub P, et al. Cryoglobulinemia in chronic
liver diseases: role of hepatitis C virus and liver damage.
Gastroenterology 1994; 106:1291-1300.
TREATMENT OF ACUTE HEPATITIS C
Viladomiu L, Genesca J, Estaban JI, et al. Interferon alpha in acute
posttransfusion hepatitis C: a randomized controlled trial. Hepatology
1992; 15:767-769.
Omata M, Yokosuka O, Takano S et al. Resolution of acute hepatitis
C after therapy with natural beta interferon. Lancet 1991;
338:914-915.
Lampertico P, Rumi M, Romeo R, Craxi A, Soffrededini R, Biassoni
D, Colombo M. A multicenter randomized controlled trial of
recombinant interferon alpha-2b in patients with acute transfusion-
associated hepatitis C. Hepatology 1994; 19:19-22.
Tassopoulos NC, Koutelou MG, Papatheodoridis G, et al. Recombinant
human interferon alfa-2b treatment for acute non-A, non-B
hepatitis. Gut 1993; 34:S130-132.
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